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1972•Journal of the Chemical Society Perkin Transactions 1Requires access

Carcinogenic nitrogen compounds. Part LXXIII. Cyclisation of 12-(o-chloroaryl)benz[a]acridines: a route to new condensed acridines derived from naphtho[2,1,8-def]quinoline (1-azapyrene)

Ng. Ph. Buu‐Hoï, Odette Périn‐Roussel, P. Jacquignon

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Abstract

12-(o-Chlorophenyl)benz[a]acridine undergoes cyclisation with sodium hydroxide in benzo[h]quinoline to give 10-azadibenzo[a,l]pyrene, a new type of condensed polycyclic acridine derived from naphtho[2,1,8-def]quinoline. This reaction can be extended to the synthesis of substituted derivatives of this new heterocyclic system such as benzo[j]phenanthra [9,10,1-mna] acridine.

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12-(o-Chlorophenyl)benz[a]acridine undergoes cyclisation with sodium hydroxide in benzo[h]quinoline to give 10-azadibenzo[a,l]pyrene, a new type of condensed polycyclic acridine derived from naphtho[2,1,8-def]quinoline. This reaction can be extended to the synthesis of substituted derivatives of this new heterocyclic system such as benzo[j]phenanthra [9,10,1-mna] acridine.

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Available abstract

12-(o-Chlorophenyl)benz[a]acridine undergoes cyclisation with sodium hydroxide in benzo[h]quinoline to give 10-azadibenzo[a,l]pyrene, a new type of condensed polycyclic acridine derived from naphtho[2,1,8-def]quinoline. This reaction can be extended to the synthesis of substituted derivatives of this new heterocyclic system such as benzo[j]phenanthra [9,10,1-mna] acridine.

Key concepts: Acridine, Quinoline, Chemistry, Acridine derivatives, Medicinal chemistry, Pyrene, Carcinogen, Stereochemistry

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Carcinogenic nitrogen compounds. Part LXXIII. Cyclisation of 12-(o-chloroaryl)benz[a]acridines: a route to new condensed acridines derived from naphtho[2,1,8-def]quinoline (1-azapyrene) — Research Paper | ScholarLens