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1978•Clinical and Experimental DermatologyRequires access

A randomized, controlled clinical trial comparing photochemotherapy with dithranol in the initial treatment of chronic plaque psoriasis

Dino Vella Briffa, S. Rogers, Malcolm Watson Greaves, JANET M. MARKS, Sam Shuster, ANDREW P. WARIN

Open publisher page 26 citations

Abstract

224 patients with widespread plaque psoriasis were randomly allocated to treatment with PUVA or dithranol. 103 of the 113 patients treated with PUVA (91.2%) cleared satisfactorily compared with 91 out of in patients treated with dithranol (82%). However, dithranol cleared psoriasis significantly faster than PUVA (20.4±0.9 days compared to 34.4±1.8 days). Photochemotherapy produced no evident short‐term adverse effects on the bone marrow, liver, or kidneys.

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What this paper is about

224 patients with widespread plaque psoriasis were randomly allocated to treatment with PUVA or dithranol. 103 of the 113 patients treated with PUVA (91.2%) cleared satisfactorily compared with 91 out of in patients treated with dithranol (82%). However, dithranol cleared psoriasis significantly faster than PUVA (20.4±0.9 days compared to 34.4±1.8 days). Photochemotherapy produced no evident short‐term adverse effects on the bone marrow, liver, or kidneys.

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OpenAlex reports 26 citations for this work. Citation counts describe recorded attention and do not establish research quality.

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Available abstract

224 patients with widespread plaque psoriasis were randomly allocated to treatment with PUVA or dithranol. 103 of the 113 patients treated with PUVA (91.2%) cleared satisfactorily compared with 91 out of in patients treated with dithranol (82%). However, dithranol cleared psoriasis significantly faster than PUVA (20.4±0.9 days compared to 34.4±1.8 days). Photochemotherapy produced no evident short‐term adverse effects on the bone marrow, liver, or kidneys.

Key concepts: Dithranol, Psoriasis, Clearance, Medicine, Dermatology, Plaque psoriasis, Adverse effect, Methoxsalen

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A randomized, controlled clinical trial comparing photochemotherapy with dithranol in the initial treatment of chronic plaque psoriasis — Research Paper | ScholarLens