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EFFECT OF RESERPINE ON PITUITARY PROLACTIN CONTENT AND ITS HYPOTHALAMIC SITE OF ACTION IN THE RABBIT

S. Kanematsu, Jessamine Hilliard, C. H. Sawyer

Open publisher page 29 citations

Abstract

ABSTRACT A single intravenous dose of reserpine (0.5 mg/kg) lowers the level of pituitary prolactin and induces lactation in ovariectomized, oestrogen-primed rabbits. These effects can also be produced by placing a discrete electrolytic lesion in the basal tuberal hypothalamus, and following such a lesion, reserpine exerts no further effects on pituitary prolactin or mammary gland activation. In contrast, when reserpine is administered to rabbits bearing lesions elsewhere in the hypothalamus, depletion of pituitary prolactin and lactation ensues. These results suggest that reserpine-induced prolactin depletion of the pituitary gland, with subsequent lactation, is mediated by a system within the basal tuberal hypothalamus.

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What this paper is about

ABSTRACT A single intravenous dose of reserpine (0.5 mg/kg) lowers the level of pituitary prolactin and induces lactation in ovariectomized, oestrogen-primed rabbits. These effects can also be produced by placing a discrete electrolytic lesion in the basal tuberal hypothalamus, and following such a lesion, reserpine exerts no further effects on pituitary prolactin or mammary gland activation. In contrast, when reserpine is administered to rabbits bearing lesions elsewhere in the hypothalamus, depletion of pituitary prolactin and lactation ensues. These results suggest that reserpine-induced prolactin depletion of the pituitary gland, with subsequent lactation, is mediated by a system within the basal tuberal hypothalamus.

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Available abstract

ABSTRACT A single intravenous dose of reserpine (0.5 mg/kg) lowers the level of pituitary prolactin and induces lactation in ovariectomized, oestrogen-primed rabbits. These effects can also be produced by placing a discrete electrolytic lesion in the basal tuberal hypothalamus, and following such a lesion, reserpine exerts no further effects on pituitary prolactin or mammary gland activation. In contrast, when reserpine is administered to rabbits bearing lesions elsewhere in the hypothalamus, depletion of pituitary prolactin and lactation ensues. These results suggest that reserpine-induced prolactin depletion of the pituitary gland, with subsequent lactation, is mediated by a system within the basal tuberal hypothalamus.

Key concepts: Reserpine, Endocrinology, Internal medicine, Prolactin, Hypothalamus, Lactation, Prolactin cell, Pituitary gland

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EFFECT OF RESERPINE ON PITUITARY PROLACTIN CONTENT AND ITS HYPOTHALAMIC SITE OF ACTION IN THE RABBIT — Research Paper | ScholarLens