2010•Renal FailureOpen access

Triggering of atypical hemolytic uremic syndrome by influenza A (H1N1)

Diogo Bento, Joana Mapril, Carla Rocha, Kevin J. Marchbank, David Kavanagh, D Barge, Lisa Strain, Timothy H.J. Goodship, Carlos Meneses-Oliveira

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Abstract

We report a case of atypical hemolytic uremic syndrome (aHUS) triggered by influenza A (H1N1) in a 17-year-old boy with a mutation in the gene (CD46) encoding the transmembrane complement regulator membrane cofactor protein. The patient recovered completely following treatment with oseltamivir, plasma exchange, and hemodialysis. We describe the case and discuss this unusual association of diseases.

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Key concepts: Atypical hemolytic uremic syndrome, Medicine, Uremic toxins, CD46, Eculizumab, Hemodialysis, Immunology, Oseltamivir