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1966•Recueil des Travaux Chimiques des Pays-BasRequires access

1,1,2‐Triphenylethylenes with trifluoromethyl substituents

Ng. Ph. Buu‐Hoï, Nguyễn Hoàng Nam, Ng. D. Xuong

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Abstract

Abstract A number of 1,1,2‐triphenylethylenes bearing trifluoromethyl substituents in various positions have been synthesized and their oestrogenic activity investigated. It is shown that the introduction of trifluoromethyl groups decreases the oestrogenicity, this effect being more pronounced in the para derivatives than in the ortho and meta isomers. Possible explanations for this effect are discussed.

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What this paper is about

Abstract A number of 1,1,2‐triphenylethylenes bearing trifluoromethyl substituents in various positions have been synthesized and their oestrogenic activity investigated. It is shown that the introduction of trifluoromethyl groups decreases the oestrogenicity, this effect being more pronounced in the para derivatives than in the ortho and meta isomers. Possible explanations for this effect are discussed.

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Available abstract

Abstract A number of 1,1,2‐triphenylethylenes bearing trifluoromethyl substituents in various positions have been synthesized and their oestrogenic activity investigated. It is shown that the introduction of trifluoromethyl groups decreases the oestrogenicity, this effect being more pronounced in the para derivatives than in the ortho and meta isomers. Possible explanations for this effect are discussed.

Key concepts: Trifluoromethyl, Chemistry, Bearing (navigation), Medicinal chemistry, Stereochemistry, Organic chemistry, Computer science, Alkyl

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