2011•Chemical CommunicationsRequires access

A 4-[(3R,4R)-dihydroxypyrrolidino]pyrimidin-2-one nucleobase for a CG base pair in triplex DNA

Yoshiyuki Hari, Masaaki Akabane, Yuri Hatanaka, Motoi Nakahara, Satoshi Obika

Abstract

In order to expand target sequences in triplex DNA formation, the development of a nucleobase that recognizes a CG base pair in dsDNA was attempted. A 4-[(3R,4R)-dihydroxypyrrolidino]pyrimidin-2-one nucleobase was found to recognize a CG base pair with high sequence-selectivity.

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Key concepts: Nucleobase, Base pair, DNA, Chemistry, Selectivity, Sequence (biology), Base (topology), Stereochemistry