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2012•Emerging infectious diseasesOpen access

Drug-Resistant Tuberculosis Transmission and Resistance Amplification within Families

James A. Seddon, Robin M. Warren, Donald A. Enarson, Nulda Beyers, H. Simon Schaaf

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Abstract

Drug-resistant tuberculosis is caused by transmission of resistant strains of Mycobacterium tuberculosis and by acquisition of resistance through inadequate treatment. We investigated the clinical and molecular features of the disease in 2 families after drug-resistant tuberculosis was identified in 2 children. The findings demonstrate the potential for resistance to be transmitted and amplified within families.

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Drug-resistant tuberculosis is caused by transmission of resistant strains of Mycobacterium tuberculosis and by acquisition of resistance through inadequate treatment. We investigated the clinical and molecular features of the disease in 2 families after drug-resistant tuberculosis was identified in 2 children. The findings demonstrate the potential for resistance to be transmitted and amplified within families.

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Available abstract

Drug-resistant tuberculosis is caused by transmission of resistant strains of Mycobacterium tuberculosis and by acquisition of resistance through inadequate treatment. We investigated the clinical and molecular features of the disease in 2 families after drug-resistant tuberculosis was identified in 2 children. The findings demonstrate the potential for resistance to be transmitted and amplified within families.

Key concepts: Mycobacterium tuberculosis, Tuberculosis, Drug resistance, Transmission (telecommunications), Drug, Virology, Biology, Disease

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