2003•Antimicrobial Agents and ChemotherapyOpen access
Novel Pseudomonas aeruginosa Gene That Suppresses Tolerance to Carbapenems
Kazuko Taniguchi, Tsuneko Ono, Keiji Murakami, Darija Vidučić, Sizuo Kayama, Katsuhiko Hirota, Ken Nemoto, Yoichiro Miyake
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Abstract
A biapenem-tolerant mutant of Pseudomonas aeruginosa was isolated by Tn1737KH insertion. The survival of the mutant 3 h after the addition of biapenem was about 1000 times greater than that of the wild type. The mutant was also tolerant to other biapenems, such as imipenem, panipenem, and meropenem.