2002•Helvetica Chimica ActaRequires access

Determination of the Absolute Configuration of (−)-Mirtazapine by Vibrational Circular Dichroism

Teresa B. Freedman, Rina K. Dukor, Peter J. C. M. van Hoof, Edwin R. Kellenbach, Laurence A. Nafié

Abstract

The absolute configuration of the (−)-enantiomer of mirtazapine was determined by means of vibrational circular dichroism (VCD). The observed VCD of (−)-mirtazapine showed excellent correlation with the calculated VCD of the (R)-enantiomer. This is in agreement with the absolute configuration as determined by independent synthesis starting from (R)-phenylglycine.

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Key concepts: Absolute configuration, Vibrational circular dichroism, Chemistry, Mirtazapine, Circular dichroism, Enantiomer, Stereochemistry, Biology