1983•Medical and Pediatric OncologyRequires access

Combination chemotherapy pneumonitis: A case report of possible synergistic toxicity

James J. Goedert, Frederick P. Smith, Edward Tsou, Raymond B. Weiss

Abstract

A woman with pancreatic cancer developed acute interstitial infiltrates while receiving modest doses of two potential pulmonary toxins, mitomycin-C and chlorozotocin. Chemotherapy pneumonitis, confirmed by lung biopsy, responded dramatically to prednisone with negligible sequelae. Comparison with the doses in other reported cases suggested additive or synergistic toxicity between these two alkylating agents.

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Available abstract

Key concepts: Medicine, Pulmonary toxicity, Chemotherapy, Toxicity, Pneumonitis, Prednisone, Interstitial pneumonitis, Respiratory disease