2012•Journal of Medicinal Plants ResearchOpen access

Antimicrobial activity of artocarpesin from Artocarpus heterophyllus Lam. against methicillin-resistant Staphylococcus aureus (MRSA)

Navarro-García Víctor Manuel

Abstract

We evaluated the antibacterial activity of the organic extracts (n-hexane, acetone and methanol) from the fruit of Artocarpus heterophyllus Lam. against Staphylococcus aureus,(methicillin-susceptible Staphylococcus aureus [MSSA]). The extract that demonstrated the greatest activity was that of acetone, with a minimum inhibitory concentration (MIC) value of 0.375 mg/ml against S. aureus MSSA. The acetone extract was further fractionated by means of open-column chromatographic methods into different fractions, and it was found that the F3 fraction was the most active. An active compound against MSSA and methicillin-resistant Staphylococcus aureus bacteria was isolated from this fraction; this compound was identified through spectroscopic methods of 1H and 13C nuclear magnetic resonance as artocarpesin. Key words: Antimicrobial activity, artocarpesin, Artocarpus heterophyllus, methicillin-resistant Staphylococcus aureus (MRSA).

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Key concepts: Staphylococcus aureus, Antimicrobial, Artocarpus, Methicillin-resistant Staphylococcus aureus, Traditional medicine, Microbiology, Medicine, Biology