ScholarLens Back to search
2008•Encyclopedia of Life SciencesRequires access

Varicella Zoster: Virus and Disease

Suzanna L. R. McDonald, Judith Breuer

Open publisher page 0 citations

Abstract

Abstract Varicella zoster virus (VZV), also known as human herpes virus 3 (HHV3), causes varicella (chicken pox) upon primary infection, establishes latency in dorsal root ganglia (DRG) and can later reactivate to cause herpes zoster (shingles). Difficulties in studying the pathogenesis of VZV; because of its high cell association and narrow host range, have been overcome through the development of the VZV severe combined immunodeficient (SCID) mouse model carrying human tissue implants. VZV is the first human herpes virus for which a live attenuated vaccine has been developed.

About this research paper

What this paper is about

Abstract Varicella zoster virus (VZV), also known as human herpes virus 3 (HHV3), causes varicella (chicken pox) upon primary infection, establishes latency in dorsal root ganglia (DRG) and can later reactivate to cause herpes zoster (shingles). Difficulties in studying the pathogenesis of VZV; because of its high cell association and narrow host range, have been overcome through the development of the VZV severe combined immunodeficient (SCID) mouse model carrying human tissue implants. VZV is the first human herpes virus for which a live attenuated vaccine has been developed.

Why it matters

A significance statement is not available in the OpenAlex record.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

Abstract Varicella zoster virus (VZV), also known as human herpes virus 3 (HHV3), causes varicella (chicken pox) upon primary infection, establishes latency in dorsal root ganglia (DRG) and can later reactivate to cause herpes zoster (shingles). Difficulties in studying the pathogenesis of VZV; because of its high cell association and narrow host range, have been overcome through the development of the VZV severe combined immunodeficient (SCID) mouse model carrying human tissue implants. VZV is the first human herpes virus for which a live attenuated vaccine has been developed.

Key concepts: Varicella zoster virus, Virology, Shingles, Virus, Chickenpox, Latency (audio), Disease, Biology

Related papers

Related paper 1Related paper 2Related paper 3
Back to paper searchBrowse research topicsOriginal source
Varicella Zoster: Virus and Disease — Research Paper | ScholarLens