2004•Mini-Reviews in Medicinal ChemistryRequires access

New Developments on Thromboxane Modulators

Jean‐Michel Dogné, Julien Hanson, Xavier de Leval, Bernard Masereel, Philippe Kolh, Bernard Pirotte

Abstract

Thromboxane A(2) (TXA(2)) is a labile product formed from arachidonic acid by cyclooxygenase. The pathogenesis of numerous cardiovascular, pulmonary, and thromboembolic diseases can be related to this metabolite. Therefore, TXA(2) modulators have been developed for 20 years. This review will highlight the evolution in the field of TXA(2) modulators.

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Key concepts: Chemistry, Pharmacology, Medicine