1970•Canadian Journal of BiochemistryRequires access

Hemoglobin Broussais: α90 Lys → Asn

Francis Vella, Deborah Charlesworth, P.A. Lorkin, H. Lehmann

Abstract

A hemoglobin with the electrophoretic properties of hemoglobin K or J was found in three generations of a Canadian family in Saskatoon. By analysis of the tryptic peptides of the whole globin and of the isolated abnormal α chains, it was characterized as α90 Lys → Asn (hemoglobin Broussais). This is the second report of the occurrence of this hemoglobin variant.

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Key concepts: Hemoglobin, Hemoglobin variants, Hemoglobin s, Globin, Hemoglobin A2, Hemoglobin A, Chemistry, Biochemistry