2008•Antimicrobial Agents and ChemotherapyOpen access

Mouse Beta-Defensin-14, an Antimicrobial Ortholog of Human Beta-Defensin-3

Kerstin Hinrichsen, Rainer Podschun, Sabine Schubert, Jens‐Michael Schröder, Jürgen Harder, Ehrhardt Proksch

Abstract

Searching the database for mouse homologs of the antimicrobial peptide human beta-defensin-3 (hBD-3) revealed highest identity (69%) to mouse beta-defensin-14 (mBD-14). Recombinant mBD-14 exhibited broad-spectrum, nanomolar microbicidal activity. Treatment of keratinocytes with gamma interferon or transforming growth factor alpha increased mBD-14 gene expression. These data suggest that mBD-14 is the functional ortholog of hBD-3.

About this research paper

What this paper is about

Why it matters

OpenAlex reports 54 citations for this work. Citation counts describe recorded attention and do not establish research quality.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

Key concepts: Defensin, Beta defensin, Biology, BETA (programming language), Gene, Antimicrobial, Antimicrobial peptides, Recombinant DNA