2013•Organic LettersRequires access
Pd(II)-Catalyzed Ph2(O)P-Directed C–H Olefination toward Phosphine–Alkene Ligands
Hongli Wang, Rongbin Hu, Heng Zhang, An‐Xi Zhou, Shang‐Dong Yang
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Abstract
The Pd(II)-catalyzed Ph2(O)P-directed C-H olefination to synthesize alkene-phosphine compounds is reported. In contrast to previous examples of various directing groups that guide selective C-H activation, the Ph2(O)P group not only acts as the directing group but also serves to construct the alkene-phosphine ligands. The monoprotected amino acid (MPAA) ligand Ac-Leu-OH is found to promote this reaction in a significant manner.