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2005•Molecular CellOpen access

Mechanism of Sirtuin Inhibition by Nicotinamide: Altering the NAD+ Cosubstrate Specificity of a Sir2 Enzyme

José L. Avalos‬, Katherine M. Bever, Cynthia Wolberger

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Key concepts: NAD+ kinase, Nicotinamide, Sirtuin, Cofactor, Biochemistry, Nicotinamide adenine dinucleotide, Biology, Enzyme

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