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Detection of bacterial antigens in body fluids with the Wellcogen Haemophilus influenzae b, Streptococcus pneumoniae, and Neisseria meningitidis (ACYW135) latex agglutination tests

David L. Ingram, A. W. Pearson, Angela R Occhiuti

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Abstract

The Wellcogen Haemophilus influenzae b, Streptococcus pneumoniae, and Neisseria meningitidis (ACYW135) latex agglutination tests (Wellcome Diagnostics, Dartford, England) were evaluated as methods to detect bacterial antigens in cerebrospinal fluid (CSF), urine, and serum from patients with meningitis or sepsis. Antigen was detected in 92% of CSFs from H. influenzae b, 100% of CSFs from N. meningitidis groups A and Y, 36% of CSFs from N. meningitidis group C, and 69% of CSFs from pneumococcal meningitidis patients. Serum samples presented a problem, with a few false-positive or possible cross-reactions. The Wellcogen latex agglutination tests were more sensitive than the Bactogen (H. influenzae type b) latex agglutination test and the Phadebact (S. pneumoniae) coagglutination test.

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What this paper is about

The Wellcogen Haemophilus influenzae b, Streptococcus pneumoniae, and Neisseria meningitidis (ACYW135) latex agglutination tests (Wellcome Diagnostics, Dartford, England) were evaluated as methods to detect bacterial antigens in cerebrospinal fluid (CSF), urine, and serum from patients with meningitis or sepsis. Antigen was detected in 92% of CSFs from H. influenzae b, 100% of CSFs from N. meningitidis groups A and Y, 36% of CSFs from N. meningitidis group C, and 69% of CSFs from pneumococcal meningitidis patients. Serum samples presented a problem, with a few false-positive or possible cross-reactions. The Wellcogen latex agglutination tests were more sensitive than the Bactogen (H. influenzae type b) latex agglutination test and the Phadebact (S. pneumoniae) coagglutination test.

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Available abstract

The Wellcogen Haemophilus influenzae b, Streptococcus pneumoniae, and Neisseria meningitidis (ACYW135) latex agglutination tests (Wellcome Diagnostics, Dartford, England) were evaluated as methods to detect bacterial antigens in cerebrospinal fluid (CSF), urine, and serum from patients with meningitis or sepsis. Antigen was detected in 92% of CSFs from H. influenzae b, 100% of CSFs from N. meningitidis groups A and Y, 36% of CSFs from N. meningitidis group C, and 69% of CSFs from pneumococcal meningitidis patients. Serum samples presented a problem, with a few false-positive or possible cross-reactions. The Wellcogen latex agglutination tests were more sensitive than the Bactogen (H. influenzae type b) latex agglutination test and the Phadebact (S. pneumoniae) coagglutination test.

Key concepts: Neisseria meningitidis, Latex fixation test, Haemophilus influenzae, Streptococcus pneumoniae, Microbiology, Direct agglutination test, Meningitis, Neisseriaceae

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Detection of bacterial antigens in body fluids with the Wellcogen Haemophilus influenzae b, Streptococcus pneumoniae, and Neisseria meningitidis (ACYW135) latex agglutination tests — Research Paper | ScholarLens