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1986•Journal of the Chemical Society Perkin Transactions 1Requires access

Two new insect growth regulator meliacins from Azadirachta indica A. Juss (meliaceae)

Salimuzzaman Siddiqui, Shaheen Faizi, Tariq Mahmood, Bina S. Siddiqui

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Abstract

Two new bitter meliacins, nimocinolide (1) and isonimocinolide (2), have been isolated from the fresh leaves of Azadirachta indica(neem). A new meliacin, nimocin (6) has further been isolated from its fresh fruits along with the known azadirone, gedunin, epoxyazadiradione, 7-deacetyl-7-benzoylazadiradione, azadiradione, 17-hydroxyazadiradione, and β-sitosterol. The structures of these tetranortriterpenoids were elucidated through chemical and spectral studies. Compounds (1) and (2) acted as insect growth regulators against houseflies (Musca domestica) and mosquitoes (Aedes aegypti).

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What this paper is about

Two new bitter meliacins, nimocinolide (1) and isonimocinolide (2), have been isolated from the fresh leaves of Azadirachta indica(neem). A new meliacin, nimocin (6) has further been isolated from its fresh fruits along with the known azadirone, gedunin, epoxyazadiradione, 7-deacetyl-7-benzoylazadiradione, azadiradione, 17-hydroxyazadiradione, and β-sitosterol. The structures of these tetranortriterpenoids were elucidated through chemical and spectral studies. Compounds (1) and (2) acted as insect growth regulators against houseflies (Musca domestica) and mosquitoes (Aedes aegypti).

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Available abstract

Two new bitter meliacins, nimocinolide (1) and isonimocinolide (2), have been isolated from the fresh leaves of Azadirachta indica(neem). A new meliacin, nimocin (6) has further been isolated from its fresh fruits along with the known azadirone, gedunin, epoxyazadiradione, 7-deacetyl-7-benzoylazadiradione, azadiradione, 17-hydroxyazadiradione, and β-sitosterol. The structures of these tetranortriterpenoids were elucidated through chemical and spectral studies. Compounds (1) and (2) acted as insect growth regulators against houseflies (Musca domestica) and mosquitoes (Aedes aegypti).

Key concepts: Azadirachta, Meliaceae, Insect growth regulator, Musca, Aedes aegypti, Biology, Botany, Traditional medicine

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Two new insect growth regulator meliacins from Azadirachta indica A. Juss (meliaceae) — Research Paper | ScholarLens