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1991•Journal of Clinical PathologyOpen access

Inhibition of urease activity but not growth of Helicobacter pylori by acetohydroxamic acid.

J.H. Goldie, S J Veldhuyzen van Zanten, S Jalali, Harold Richardson, R H Hunt

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Abstract

The in vitro effects of acetohydroxamic acid (AHA), a potent urease inhibitor, were studied to determine the effect on the urease activity and growth of 38 strains of Helicobacter pylori. AHA in concentrations of 50-1000 mg/l had a noticeably reversible inhibitory effect on the urease activity of the organism but no effect on growth.

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The in vitro effects of acetohydroxamic acid (AHA), a potent urease inhibitor, were studied to determine the effect on the urease activity and growth of 38 strains of Helicobacter pylori. AHA in concentrations of 50-1000 mg/l had a noticeably reversible inhibitory effect on the urease activity of the organism but no effect on growth.

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Available abstract

The in vitro effects of acetohydroxamic acid (AHA), a potent urease inhibitor, were studied to determine the effect on the urease activity and growth of 38 strains of Helicobacter pylori. AHA in concentrations of 50-1000 mg/l had a noticeably reversible inhibitory effect on the urease activity of the organism but no effect on growth.

Key concepts: Acetohydroxamic acid, Urease, Helicobacter pylori, Microbiology, Chemistry, In vitro, Enzyme, Biochemistry

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