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2007•Antimicrobial Agents and ChemotherapyOpen access

Effect of Antibiotics on Staphylococcus aureus Producing Panton-Valentine Leukocidin

Oana Dumitrescu, Sandrine Boisset, Cédric Badiou, Michèle Bes, Yvonne Benito, M.E. Reverdy, François Vandenesch, Jérôme Étienne, Gérard Lina

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Abstract

We examined the capacity of Staphylococcus aureus strains to release Panton-Valentine leukocidin (PVL) in the presence of antibiotics. No PVL was detected when S. aureus was incubated at inhibitory concentrations, while subinhibitory concentrations of oxacillin enhanced the PVL level; clindamycin, linezolid, and fusidic acid were inhibitory; and vancomycin had roughly no effect.

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What this paper is about

We examined the capacity of Staphylococcus aureus strains to release Panton-Valentine leukocidin (PVL) in the presence of antibiotics. No PVL was detected when S. aureus was incubated at inhibitory concentrations, while subinhibitory concentrations of oxacillin enhanced the PVL level; clindamycin, linezolid, and fusidic acid were inhibitory; and vancomycin had roughly no effect.

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Available abstract

We examined the capacity of Staphylococcus aureus strains to release Panton-Valentine leukocidin (PVL) in the presence of antibiotics. No PVL was detected when S. aureus was incubated at inhibitory concentrations, while subinhibitory concentrations of oxacillin enhanced the PVL level; clindamycin, linezolid, and fusidic acid were inhibitory; and vancomycin had roughly no effect.

Key concepts: Panton–Valentine leukocidin, Microbiology, Staphylococcus aureus, Antibiotics, Leukocidin, Staphylococcal infections, Biology, Methicillin-resistant Staphylococcus aureus

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