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2009•BMC NeuroscienceOpen access

Towards a computational model for stimulation of the Pedunculopontine nucleus

M.A.J. Lourens, Hil G. E. Meijer, Tjitske Heida, Stephan A. van Gils

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Abstract

The pedunculopontine nucleus (PPN) has recently been suggested as a new therapeutic target for deep brain stimulation (DBS) in patients suffering from Parkinson's disease, particularly those with severe gait and postural impairment [ 1 ]. Stimulation at this site is typically delivered at low frequencies in contrast to the high frequency stimulation required for therapeutic benefit in the subthalamic nucleus (STN) [ 1 ].

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What this paper is about

The pedunculopontine nucleus (PPN) has recently been suggested as a new therapeutic target for deep brain stimulation (DBS) in patients suffering from Parkinson's disease, particularly those with severe gait and postural impairment [ 1 ]. Stimulation at this site is typically delivered at low frequencies in contrast to the high frequency stimulation required for therapeutic benefit in the subthalamic nucleus (STN) [ 1 ].

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Available abstract

The pedunculopontine nucleus (PPN) has recently been suggested as a new therapeutic target for deep brain stimulation (DBS) in patients suffering from Parkinson's disease, particularly those with severe gait and postural impairment [ 1 ]. Stimulation at this site is typically delivered at low frequencies in contrast to the high frequency stimulation required for therapeutic benefit in the subthalamic nucleus (STN) [ 1 ].

Key concepts: Pedunculopontine nucleus, Deep brain stimulation, Subthalamic nucleus, Neuroscience, Stimulation, Basal ganglia, Parkinson's disease, Pedunculopontine Tegmental Nucleus

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