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1986•Journal of Antimicrobial ChemotherapyRequires access

Mechanisms by which imipenem may overcome resistance in Gram-negative bacilli

R. Williams, Youjun Yang, David M. Livermore

Open publisher page 16 citations

Abstract

Imipenem is one of the carbapenem class of new beta-lactam antibiotics. It is a potent antibacterial with a broad spectrum of activity. Against Gram-negative rods, it appears to be able to circumvent the classical resistance mechanisms by way of its high affinity for PBP 2 and its good penetration of the cell wall. Imipenem is stable to hydrolysis by the common plasmid-mediated beta-lactamases and is a potent inducer of, but stable to the action of, chromosomal beta-lactamases.

About this research paper

What this paper is about

Imipenem is one of the carbapenem class of new beta-lactam antibiotics. It is a potent antibacterial with a broad spectrum of activity. Against Gram-negative rods, it appears to be able to circumvent the classical resistance mechanisms by way of its high affinity for PBP 2 and its good penetration of the cell wall. Imipenem is stable to hydrolysis by the common plasmid-mediated beta-lactamases and is a potent inducer of, but stable to the action of, chromosomal beta-lactamases.

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OpenAlex reports 16 citations for this work. Citation counts describe recorded attention and do not establish research quality.

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Available abstract

Imipenem is one of the carbapenem class of new beta-lactam antibiotics. It is a potent antibacterial with a broad spectrum of activity. Against Gram-negative rods, it appears to be able to circumvent the classical resistance mechanisms by way of its high affinity for PBP 2 and its good penetration of the cell wall. Imipenem is stable to hydrolysis by the common plasmid-mediated beta-lactamases and is a potent inducer of, but stable to the action of, chromosomal beta-lactamases.

Key concepts: Imipenem, Microbiology, Bacilli, Medicine, Gram-negative bacterial infections, Gram-negative bacteria, Antibiotic resistance, Biology

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