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1972•Canadian Journal of MicrobiologyRequires access

Inhibitory effects of anticellular antibodies on colony formation of mouse leukemia L5178YR cells in soft agar

Tao Yang, Stephen I. Vas

Open publisher page 7 citations

Abstract

Heat-inactivated antiserum in the absence of complement inhibits colony formation of mouse leukemia L5178YR cells in soft agar. Cells derived from resistant clones in these plates showed the same sensitivity to antiserum as the parent population. Agglutination of the cells was prevented by placing the antiserum dilutions over the cell-containing agar layer. This clearly indicates that cell agglutination by antiserum is not necessarily the essential cause of growth inhibition.

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What this paper is about

Heat-inactivated antiserum in the absence of complement inhibits colony formation of mouse leukemia L5178YR cells in soft agar. Cells derived from resistant clones in these plates showed the same sensitivity to antiserum as the parent population. Agglutination of the cells was prevented by placing the antiserum dilutions over the cell-containing agar layer. This clearly indicates that cell agglutination by antiserum is not necessarily the essential cause of growth inhibition.

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OpenAlex reports 7 citations for this work. Citation counts describe recorded attention and do not establish research quality.

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Available abstract

Heat-inactivated antiserum in the absence of complement inhibits colony formation of mouse leukemia L5178YR cells in soft agar. Cells derived from resistant clones in these plates showed the same sensitivity to antiserum as the parent population. Agglutination of the cells was prevented by placing the antiserum dilutions over the cell-containing agar layer. This clearly indicates that cell agglutination by antiserum is not necessarily the essential cause of growth inhibition.

Key concepts: Antiserum, Agglutination (biology), Agar, Biology, Antibody, Molecular biology, Population, Microbiology

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