1970•JNCI Journal of the National Cancer InstituteRequires access

Relation Between Neutralization of Epstein-Barr Virus and Antibodies to Cell-Membrane Antigens Induced by the Virus 2

Gary R. Pearson, Faye Dewey, George Klein, Gertrude Henle, Werner Henle

Abstract

The neutralization of Epstein-Barr virus (EBV) infectivity by sera with known antibody activities against EBV-associated antigens was investigated in experimentally infected Raji and RPMI 64-10 cells. Antibodies against EBV-induced cell-membrane antigens were apparently responsible for neutralization of viral infectivity. Antibodies against EBV capsid antigens and EBV-induced early antigens were not involved. The implication of these results on the relationship of the membrane antigens to the infectious virus particle is discussed.

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Key concepts: Infectivity, Virology, Antigen, Virus, Antibody, Neutralization, Epstein–Barr virus, Capsid