1981•Philosophical transactions of the Royal Society of London. Series B, Biological sciencesRequires access

Inherited abnormalities of platelet glycoproteins

Jacques Caen, Alan T. Nurden, Thomas J. Kunicki

Abstract

Glanzmann's thrombasthenia and the Bernard-Soulier syndrome are inherited blood disorders characterized by abnormalities in different aspects of platelet function during haemostasis. Platelets from patients with thrombasthenia do not aggregate in response to the normal physiological platelet aggregation inducing stimuli, while Bernard-Soulier platelet have a reduced capacity to adhere to exposed subendothelium. Deficiencies of different membrane glycoproteins have been located in the platelets of both disorders and suggest specific roles for membrane glycoproteins in different aspects of platelet function.

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Key concepts: Thrombasthenia, Bernard–Soulier syndrome, Platelet, Glycoprotein, Platelet membrane glycoprotein, Blood Platelet Disorders, Medicine, Function (biology)