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The antidotal action of para-aminopropiophenone with or without sodium thiosulfate in cyanide poisoning.
Charles L. Rose, J. S. Welles
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Abstract
1. Dogs poisoned by subcutaneous injection of sodium cyanide can be saved by intravenous administration of p -aminopropiophenone, provided the dose of the poison is under 4 LD50's.
2. Potentiation of antidotal action against cyanide occurs when p -aminopropiophenone and sodium thiosulfate are successively injected by vein. The amount of sodium cyanide detoxified by this combination is about the same as that by sodium nitrite and sodium thiosulfate.