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Effect of 1-2-4 Dinitrophenol on Cellular Respiration

R.H. De Meio, E. S. Guzmán Barrón

Open publisher page 16 citations

Abstract

Since dinitrophenol is unable to oxidize such a labile compound as lactate activated by a-hydroxyoxidase; is without effect Lvhen the respiration of cells and tissues has been inhibited by cyanide or carbon monoxide; and has no action on the respiration of certain bacteria, where the complicated controlling mechanisms present in highly organized cells are absent, it is concluded that the increase in respiration produced by dinitrophenol is not due to direct oxidation of the oxidizable substrates. It is suggested that dinitrophenol acts by combining with some of the substances acting as agents for the control of the speed of cellular oxidations, thus increasing the activity of the oxidizing enzymes.

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What this paper is about

Since dinitrophenol is unable to oxidize such a labile compound as lactate activated by a-hydroxyoxidase; is without effect Lvhen the respiration of cells and tissues has been inhibited by cyanide or carbon monoxide; and has no action on the respiration of certain bacteria, where the complicated controlling mechanisms present in highly organized cells are absent, it is concluded that the increase in respiration produced by dinitrophenol is not due to direct oxidation of the oxidizable substrates. It is suggested that dinitrophenol acts by combining with some of the substances acting as agents for the control of the speed of cellular oxidations, thus increasing the activity of the oxidizing enzymes.

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OpenAlex reports 16 citations for this work. Citation counts describe recorded attention and do not establish research quality.

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Available abstract

Since dinitrophenol is unable to oxidize such a labile compound as lactate activated by a-hydroxyoxidase; is without effect Lvhen the respiration of cells and tissues has been inhibited by cyanide or carbon monoxide; and has no action on the respiration of certain bacteria, where the complicated controlling mechanisms present in highly organized cells are absent, it is concluded that the increase in respiration produced by dinitrophenol is not due to direct oxidation of the oxidizable substrates. It is suggested that dinitrophenol acts by combining with some of the substances acting as agents for the control of the speed of cellular oxidations, thus increasing the activity of the oxidizing enzymes.

Key concepts: 2,4-Dinitrophenol, Dinitrophenol, Respiration, Oxidizing agent, Chemistry, Cyanide, Biochemistry, Cellular respiration

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