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2004•Journal of Clinical MicrobiologyOpen access

Identification of a Mycobacterium tuberculosis Strain with Stable, Low-Level Resistance to Isoniazid

Bereneice M. Madison, Salman H. Siddiqi, Leonid Heifets, Wendy Gross, Mike Higgins, Nancy G. Warren, ANTHONY B. THOMPSON, Glenn P. Morlock, John C. Ridderhof

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Abstract

We have identified a potential quality control strain of Mycobacterium tuberculosis to monitor isoniazid susceptibility testing. This strain (strain A) has a stable phenotypic low-level resistance to isoniazid, has a mutation of C (-15) --> T in the inhA promoter region, and gave consistent susceptibility test results in 141 laboratories.

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We have identified a potential quality control strain of Mycobacterium tuberculosis to monitor isoniazid susceptibility testing. This strain (strain A) has a stable phenotypic low-level resistance to isoniazid, has a mutation of C (-15) --> T in the inhA promoter region, and gave consistent susceptibility test results in 141 laboratories.

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Available abstract

We have identified a potential quality control strain of Mycobacterium tuberculosis to monitor isoniazid susceptibility testing. This strain (strain A) has a stable phenotypic low-level resistance to isoniazid, has a mutation of C (-15) --> T in the inhA promoter region, and gave consistent susceptibility test results in 141 laboratories.

Key concepts: Isoniazid, Mycobacterium tuberculosis, INHA, Strain (injury), Tuberculosis, Microbiology, Biology, Virology

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