2005•Clinical Infectious DiseasesRequires access
Zygomycosis after Prolonged Use of Voriconazole in Immunocompromised Patients with Hematologic Disease: Attention Required
S. Vigouroux, Olivier Morin, Philippe Moreau, Francoise Marie Mechinaud, Nadine Morineau, Beatrice Mahé, Patrice Chevallier, Thierry A. Guillaume, Viviane Dubruille, J.-L. Harousseau, Noel Jean Milpied
Open publisher page 121 citations
Abstract
We describe 4 cases of zygomycosis that occurred after prolonged use of voriconazole in severely immunocompromised patients with hematologic disease. An invasive infection was present in 3 patients who died soon after the diagnosis at 12, 13, and 45 days. Physicians should be mindful of this potential risk after treatment with voriconazole.