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Effects of Flunitrazepam and Triazolam in Man: Are They Influenced by the Time of Ingestion?

Egil Wickstrem, J. E. Bredesen, Jan O. Gordeladze

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Abstract

Five healthy young volunteers were given flunitrazepam 1 mg, triazolam 0.25 mg or placebo at 2 a.m. or 9 a.m. in a double blind, cross-over study. The aim was to investigate the cyclic variations mainly in residual effects of the drugs, but also in sleep onset latency and pharmacokinetics. The study suggested cyclic variations in mood, psychometric tests and in sleep onset latency.

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What this paper is about

Five healthy young volunteers were given flunitrazepam 1 mg, triazolam 0.25 mg or placebo at 2 a.m. or 9 a.m. in a double blind, cross-over study. The aim was to investigate the cyclic variations mainly in residual effects of the drugs, but also in sleep onset latency and pharmacokinetics. The study suggested cyclic variations in mood, psychometric tests and in sleep onset latency.

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Available abstract

Five healthy young volunteers were given flunitrazepam 1 mg, triazolam 0.25 mg or placebo at 2 a.m. or 9 a.m. in a double blind, cross-over study. The aim was to investigate the cyclic variations mainly in residual effects of the drugs, but also in sleep onset latency and pharmacokinetics. The study suggested cyclic variations in mood, psychometric tests and in sleep onset latency.

Key concepts: Triazolam, Flunitrazepam, Placebo, Mood, Ingestion, Sleep (system call), Pharmacokinetics, Anesthesia

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Effects of Flunitrazepam and Triazolam in Man: Are They Influenced by the Time of Ingestion? — Research Paper | ScholarLens