Clinical Implications of CYP Induction‐Mediated Drug–Drug Interactions

Abstract Cytochrome P450 (CYP) induction‐mediated drug interaction is a major concern in clinical practice. Although the reported cases of CYP induction‐mediated drug interactions are less frequent than that of CYP inhibition‐mediated drug interactions, there are two major concerns with CYP induction. First, induction may cause a reduction in therapeutic efficacy as a result of increased drug metabolism. Second, induction may create an undesirable imbalance between bioactivation and detoxification as a result of increased formation of reactive metabolites leading to an increase in the risk of metabolite‐induced toxicity. Therefore, CYP induction has been considered as an important factor for consideration during drug discovery and development. The purpose of this chapter is to review the effects of CYP induction on pharmacokinetics of drugs and its clinical implications.