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1998•Human Psychopharmacology Clinical and ExperimentalRequires access

Rhabdomyolysis without neuroleptic malignant syndrome induced by additional treatment of risperidone

Norio Yasui, Tsuyoshi Kondo, Koichi Otani, Sunao Kaneko

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Abstract

This is the first case report of rhabdomyolysis without neuroleptic malignant syndrome induced by additional treatment of risperidone. The manifestations of this side effect were symptoms of myalgia, muscle weakness and red-coloured urine with findings of markedly elevated levels of creatine kinase and myoglobin in serum as well as myoglobinuria. Early diagnosis of rhabdomyolysis, immediate discontinuation of risperidone and administration of dantrolene had favourable effects on the course of the treatment of this side effect. Copyright © 1998 John Wiley & Sons, Ltd.

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What this paper is about

This is the first case report of rhabdomyolysis without neuroleptic malignant syndrome induced by additional treatment of risperidone. The manifestations of this side effect were symptoms of myalgia, muscle weakness and red-coloured urine with findings of markedly elevated levels of creatine kinase and myoglobin in serum as well as myoglobinuria. Early diagnosis of rhabdomyolysis, immediate discontinuation of risperidone and administration of dantrolene had favourable effects on the course of the treatment of this side effect. Copyright © 1998 John Wiley & Sons, Ltd.

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Available abstract

This is the first case report of rhabdomyolysis without neuroleptic malignant syndrome induced by additional treatment of risperidone. The manifestations of this side effect were symptoms of myalgia, muscle weakness and red-coloured urine with findings of markedly elevated levels of creatine kinase and myoglobin in serum as well as myoglobinuria. Early diagnosis of rhabdomyolysis, immediate discontinuation of risperidone and administration of dantrolene had favourable effects on the course of the treatment of this side effect. Copyright © 1998 John Wiley & Sons, Ltd.

Key concepts: Rhabdomyolysis, Neuroleptic malignant syndrome, Myoglobinuria, Discontinuation, Dantrolene, myalgia, Risperidone, Medicine

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