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1988•FEMS Microbiology LettersOpen access

Effect of anti-mycobacterial antibodies on activation of the alternative pathway of the human complement system

Om Parkash, V. D. Ramanathan, D.P. Singh, Utpal Sengupta

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Abstract

Mycobacterium vaccae and BCG showed activation (at the level of C3) of the alternative pathway of the human complement system as seen by enzyme linked immunosorbent assay (ELISA).Antimycobacterial antibodies were found to have enhancing effect on C3 uptake by these mycobacteria.The homologous antibodies showed more enhancing effect in comparison to heterologous antibodies.

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Mycobacterium vaccae and BCG showed activation (at the level of C3) of the alternative pathway of the human complement system as seen by enzyme linked immunosorbent assay (ELISA).Antimycobacterial antibodies were found to have enhancing effect on C3 uptake by these mycobacteria.The homologous antibodies showed more enhancing effect in comparison to heterologous antibodies.

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Available abstract

Mycobacterium vaccae and BCG showed activation (at the level of C3) of the alternative pathway of the human complement system as seen by enzyme linked immunosorbent assay (ELISA).Antimycobacterial antibodies were found to have enhancing effect on C3 uptake by these mycobacteria.The homologous antibodies showed more enhancing effect in comparison to heterologous antibodies.

Key concepts: Antimycobacterial, Heterologous, Complement system, Antibody, Alternative complement pathway, Microbiology, Mycobacterium, Complement (music)

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