1983•MicrobiologyRequires access

Resistance of Clostridium perfringens to -Lactam Antibiotics Mediated by a Decreased Affinity of a Single Essential Penicillin-binding Protein

R. Williamson

Abstract

Benzylpenicillin-resistant mutants of Clostridium perfringens have been isolated by in vitro selection. The sole mechanism of resistance was a decreased affinity of the highest molecular weight penicillin-binding protein (PBP1) for the antibiotic.

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Key concepts: Clostridium perfringens, Microbiology, Penicillin binding proteins, Penicillin, Benzylpenicillin, Antibiotics, Clostridium, Mutant

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Resistance of Clostridium perfringens to -Lactam Antibiotics Mediated by a Decreased Affinity of a Single Essential Penicillin-binding Protein — Research Paper | ScholarLens