2007•Genome biologyOpen access

Insertional mutagenesis strategies in zebrafish

Sridhar Sivasubbu, Darius Balciunas, Adam Amsterdam, Stephen C. Ekker

Abstract

We review here some recent developments in the field of insertional mutagenesis in zebrafish. We highlight the advantages and limitations of the rich body of retroviral methodologies, and we focus on the mechanisms and concepts of new transposon-based mutagenesis approaches under development, including prospects for conditional 'gene trapping' and 'gene breaking' approaches.

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Available abstract

Key concepts: Insertional mutagenesis, Zebrafish, Mutagenesis, Transposable element, Computational biology, Biology, DNA Transposable Elements, Transposon mutagenesis