2003•Unpublished venueRequires access

Action potential heterogeneity assists frequency entrainment in the intact cardiac pacemaker

Shaun L. Cloherty, Nigel H. Lovell, Socrates Dokos, Branko G. Celler

Abstract

The role of cellular heterogeneity in frequency entrainment of the primary cardiac pacemaker has been investigated using an idealized two dimensional model of the rabbit sinoatrial node and surrounding atrial tissue. Simulation results are presented which support the hypothesis, that regional variation in action potential waveshape contributes to pacemaker synchronization in-vivo.

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Available abstract

Key concepts: Entrainment (biomusicology), Sinoatrial node, Cardiac pacemaker, Synchronization (alternating current), Cardiology, In vivo, Internal medicine, Medicine