1981•Infection and ImmunityOpen access

Failure of chlorpromazine to inhibit fluid accumulation caused by Escherichia coli heat-stable enterotoxin in suckling mice

Tae Takeda, Takuya Honda, Youhei Takeda, T Miwatani

Abstract

We studied the effect of chlorpromazine on fluid accumulation caused by purified heat-stable enterotoxin (ST) from enterotoxigenic Escherichia coli in suckling mice. We found that chlorpromazine inactivated ST itself in vitro, but did not inhibit the activity of ST in the intestines.

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Available abstract

Key concepts: Enterotoxin, Heat-stable enterotoxin, Chlorpromazine, Escherichia coli, Enterotoxigenic Escherichia coli, Biology, Microbiology, In vitro