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2000•European Journal of DermatologyRequires access

In vitro expression of members of the interleukin-1 family by dermal papilla cells and possible implications for alopecia areata

A. Steins, D. Zuder, Madelaine Hahn, T. Klyscz, M. Jünger, G. Rassner

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Abstract

Histopathologically, alopecia areata (AA) is characterized by a dense accumulation of mainly T lymphocytes around and within affected hair follicles [1]. This event is accompanied by an overexpression of ICAM-1, and class I and II MHC molecules on hair follicle keratinocytes and dermal papilla cells (DPC) [2, 3]. The cascade of immunological events is not lethal for crucial elements of the hair follicle, which is why AA is usually [...]

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Histopathologically, alopecia areata (AA) is characterized by a dense accumulation of mainly T lymphocytes around and within affected hair follicles [1]. This event is accompanied by an overexpression of ICAM-1, and class I and II MHC molecules on hair follicle keratinocytes and dermal papilla cells (DPC) [2, 3]. The cascade of immunological events is not lethal for crucial elements of the hair follicle, which is why AA is usually [...]

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Available abstract

Histopathologically, alopecia areata (AA) is characterized by a dense accumulation of mainly T lymphocytes around and within affected hair follicles [1]. This event is accompanied by an overexpression of ICAM-1, and class I and II MHC molecules on hair follicle keratinocytes and dermal papilla cells (DPC) [2, 3]. The cascade of immunological events is not lethal for crucial elements of the hair follicle, which is why AA is usually [...]

Key concepts: Alopecia areata, Dermal papillae, Hair follicle, Medicine, Major duodenal papilla, Follicle, Immunology, Endocrinology

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In vitro expression of members of the interleukin-1 family by dermal papilla cells and possible implications for alopecia areata — Research Paper | ScholarLens