2004•Antimicrobial Agents and ChemotherapyOpen access

Influence of Carbon Dioxide on the MIC of Telithromycin for Streptococcus pneumoniae : an In Vitro - In Vivo Study

Éric Batard, Marie Emmanuelle Juvin, Cédric Jacqueline, Denis Bugnon, J. Caillon, G. Potel, H Drugeon

Abstract

Incubation in CO(2) resulted in higher (> or =3 doubling dilution) MICs of telithromycin than those found in ambient air for 31.2% of 346 Streptococcus pneumoniae ermB-positive strains. An increased telithromycin MIC in CO(2) was not correlated with loss of its activity in the murine sepsis/peritonitis model.

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Key concepts: Telithromycin, Streptococcus pneumoniae, Microbiology, Ketolide, In vivo, Streptococcaceae, Incubation, Antibacterial agent