2010•NeuronOpen access

The Endocannabinoid 2-Arachidonoylglycerol Produced by Diacylglycerol Lipase α Mediates Retrograde Suppression of Synaptic Transmission

Asami Tanimura, Maya Yamazaki, Yuki Hashimotodani, Motokazu Uchigashima, Shinya Kawata, Manabu Abe, Yoshihiro Kita, Kouichi Hashimoto, Takao Shimizu, Masahiko Watanabe, Kenji Sakimura, Masanobu Kano

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Key concepts: Diacylglycerol lipase, 2-Arachidonoylglycerol, Retrograde signaling, Endocannabinoid system, Postsynaptic potential, Neurotransmission, Knockout mouse, Chemistry