ScholarLens Back to search
2003•Unpublished venueRequires access

Regulates p21, Bax, and mdm2 to Inhibit Prostate Cancer Progression and Prolong Survival

Inmaculada Hernández, Lisette A. Maddison, Yongli Wei, Francesco John DeMayo, Tobias Petras, Baolin Li, Jeffrey R. Gingrich, Jeffrey M. Rosen, Norman M. Greenberg

Open publisher page 0 citations

Abstract

Loss of heterozygosity or mutation at the p53 tumor suppressor gene locus is frequently associated with advanced human prostate cancer. Hence, replacement p53 gene therapy may prove to be efficacious for this disease. While many mutations result in p53 molecules with oncogenic properties, other variants may possess wild-type properties with increased tumor suppressor activity. We have chosen to investigate the activity of a

About this research paper

What this paper is about

Loss of heterozygosity or mutation at the p53 tumor suppressor gene locus is frequently associated with advanced human prostate cancer. Hence, replacement p53 gene therapy may prove to be efficacious for this disease. While many mutations result in p53 molecules with oncogenic properties, other variants may possess wild-type properties with increased tumor suppressor activity. We have chosen to investigate the activity of a

Why it matters

A significance statement is not available in the OpenAlex record.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

Loss of heterozygosity or mutation at the p53 tumor suppressor gene locus is frequently associated with advanced human prostate cancer. Hence, replacement p53 gene therapy may prove to be efficacious for this disease. While many mutations result in p53 molecules with oncogenic properties, other variants may possess wild-type properties with increased tumor suppressor activity. We have chosen to investigate the activity of a

Key concepts: Loss of heterozygosity, Mdm2, Suppressor, Tumor suppressor gene, Prostate cancer, Cancer research, Locus (genetics), Gene

Related papers

Related paper 1Related paper 2Related paper 3
Back to paper searchBrowse research topicsOriginal source
Regulates p21, Bax, and mdm2 to Inhibit Prostate Cancer Progression and Prolong Survival — Research Paper | ScholarLens