1980•Clinical ChemistryRequires access

Bence Jones myeloma with a tetramer of kappa-type globulin in serum.

María L. Gallango, R. Suinaga, Manuel Ramírez

Abstract

We describe a case of Bence Jones multiple myeloma involving two kappa-type monoclonal proteins. One was isolated from serum, the other from both serum and urine. After biochemical and immunochemical analyses, we concluded that one of the proteins was a tetramer, present in serum but not in urine, whereas the other was a monomer, which was excreted in large amounts in the urine during the terminal stage of the disease.

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Key concepts: Bence Jones protein, Tetramer, Urine, Multiple myeloma, Kappa, Globulin, Chemistry, Molecular biology