2001•Antimicrobial Agents and ChemotherapyOpen access

Mechanism of Action of the Des-F(6) Quinolone BMS-284756 Measured by Supercoiling Inhibition and Cleavable Complex Assays

Ping Wu, Laura Lawrence, Kenneth DenBleyker, John F. Barrett

Abstract

BMS-284756 (T-3811ME), a novel des-F(6) quinolone, was tested in the supercoiling inhibition and cleavable complex assays against Escherichia coli DNA gyrase, a target of quinolones. The results suggest that BMS-284756 has the same mechanism of action against DNA gyrase as other quinolones and a similar level of potency.

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Key concepts: DNA gyrase, DNA supercoil, Quinolone, Mechanism of action, Escherichia coli, Chemistry, DNA, Biology