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2010•Angewandte Chemie International EditionOpen access

Glycosidase Inhibition with Fullerene Iminosugar Balls: A Dramatic Multivalent Effect

Philippe Compain, Camille Decroocq, Julien Iehl, Michel Holler, Damien Hazelard, Teresa Mena Barragán, Carmen Ortiz Mellet, Jean‐François Nierengarten

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Abstract

Superball! A dodecavalent iminosugar derivative with a fullerene core (see picture) shows a binding enhancement of up to three orders of magnitude over the corresponding monovalent ligand in glycosidase inhibition assays. This is the first evidence of a significant multivalent effect in glycosidase inhibition.

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Superball! A dodecavalent iminosugar derivative with a fullerene core (see picture) shows a binding enhancement of up to three orders of magnitude over the corresponding monovalent ligand in glycosidase inhibition assays. This is the first evidence of a significant multivalent effect in glycosidase inhibition.

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Available abstract

Superball! A dodecavalent iminosugar derivative with a fullerene core (see picture) shows a binding enhancement of up to three orders of magnitude over the corresponding monovalent ligand in glycosidase inhibition assays. This is the first evidence of a significant multivalent effect in glycosidase inhibition.

Key concepts: Iminosugar, Glycoside hydrolase, Chemistry, Stereochemistry, Biophysics, Biochemistry, Enzyme, Biology

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