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1999•Journal of the Chemical Society Perkin Transactions 1Requires access

Biotransformation of the fungistatic sesquiterpenoid ginsenol by Botrytis cinerea

Josefina Aleu, Rosario Hernández‐Galán, James R. Hanson, Peter B. Hitchcock, Isidro G. Collado

Open publisher page 28 citations

Abstract

The antifungal properties of ginsenol (1) have been determined. The biotransformation of this fungistatic sesquiterpenoid by the plant pathogen Botrytis cinerea gave the 8- and 9-hydroxy derivatives (5 and 3) as the major metabolites and the 6α- and 10β-hydroxy (8 and 7) and 8- and 9-oxo derivatives (6 and 4) as minor metabolites. The structure and stereochemistry of the major compound 3 were established by X-ray crystallography.

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What this paper is about

The antifungal properties of ginsenol (1) have been determined. The biotransformation of this fungistatic sesquiterpenoid by the plant pathogen Botrytis cinerea gave the 8- and 9-hydroxy derivatives (5 and 3) as the major metabolites and the 6α- and 10β-hydroxy (8 and 7) and 8- and 9-oxo derivatives (6 and 4) as minor metabolites. The structure and stereochemistry of the major compound 3 were established by X-ray crystallography.

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Available abstract

The antifungal properties of ginsenol (1) have been determined. The biotransformation of this fungistatic sesquiterpenoid by the plant pathogen Botrytis cinerea gave the 8- and 9-hydroxy derivatives (5 and 3) as the major metabolites and the 6α- and 10β-hydroxy (8 and 7) and 8- and 9-oxo derivatives (6 and 4) as minor metabolites. The structure and stereochemistry of the major compound 3 were established by X-ray crystallography.

Key concepts: Botrytis cinerea, Biotransformation, Fungal pathogen, Botrytis, Antifungal, Fungicide, Chemistry, Pathogen

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