2004•Angewandte Chemie International EditionRequires access
Enantioselective Synthesis of Cyclopropanes by Aldehyde Homologation
Christina A. Risatti, Richard E. Taylor
Open publisher page 25 citations
Abstract
An efficient method for the enantioselective preparation of structurally diverse cyclopropanes has been developed. Sequential homoaldol coupling and activation steps result in a three-carbon homologation of an aldehyde to give a nonracemic, stereochemically rich cyclopropylcarboxaldehyde (see scheme).