Chlorpromazine, Triflupromazine, and Prochlorperazine in Chronic Psychosis

As further phenothiazine tranquilizers become available in the treatment of the psychoses, there is an increasing need for comparative studies regarding their relative efficacy. A review of the literature indicates that such studies are now available on chlorpromazine and mepazine,1,2promazine and mepazine,3and promazine and chlorpromazine.4In a previous paper by us, the effects of chlorpromazine and triflupromazine were compared in the management of the chronic, hospitalized psychotic patient.5The following study is a continuation of the previous one, utilizing the same population and adding prochlorperazine as a final treatment phase. In this present paper the main emphasis will be on the comparative effectiveness of triflupromazine and prochlorperazine with original treatment with chlorpromazine serving as a base line. As previously, effectiveness is measured in terms of certain psychological dimensions observable in ward and interview behavior. Procedure The subjects originally selected