2005Chemical SensesRequires access

Adult Neurogenesis and Gliogenesis in the Rat Olfactory Nervous System

Nanae Fukushima

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Abstract

In the olfactory nervous system, it is well established that neural stem cells continually proliferate in the periventricular region, migrate along the rostral migratory stream (RMS) and differentiate into neurons of the glomerular (OB-GL) and granule cell (OB-GCL) layers of the olfactory bulb (OB). In this paper, we will answer the following questions regarding adult neurogenesis of the olfactory nervous system. (i) What is the fate of newly generated bulbar neurons? (ii) Does neuronal regeneration occur after neuronal cell death of the forebrain regions in and around the RMS? (iii) Does neurogenesis occur within the OB independently of migrating neural stem cells? If intrabulbar neurogenesis occurs, are there some differences in neurogenesis and gliogenesis by the neural stem cells of different origins?

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What this paper is about

In the olfactory nervous system, it is well established that neural stem cells continually proliferate in the periventricular region, migrate along the rostral migratory stream (RMS) and differentiate into neurons of the glomerular (OB-GL) and granule cell (OB-GCL) layers of the olfactory bulb (OB). In this paper, we will answer the following questions regarding adult neurogenesis of the olfactory nervous system. (i) What is the fate of newly generated bulbar neurons? (ii) Does neuronal regeneration occur after neuronal cell death of the forebrain regions in and around the RMS? (iii) Does neurogenesis occur within the OB independently of migrating neural stem cells? If intrabulbar neurogenesis occurs, are there some differences in neurogenesis and gliogenesis by the neural stem cells of different origins?

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Available abstract

In the olfactory nervous system, it is well established that neural stem cells continually proliferate in the periventricular region, migrate along the rostral migratory stream (RMS) and differentiate into neurons of the glomerular (OB-GL) and granule cell (OB-GCL) layers of the olfactory bulb (OB). In this paper, we will answer the following questions regarding adult neurogenesis of the olfactory nervous system. (i) What is the fate of newly generated bulbar neurons? (ii) Does neuronal regeneration occur after neuronal cell death of the forebrain regions in and around the RMS? (iii) Does neurogenesis occur within the OB independently of migrating neural stem cells? If intrabulbar neurogenesis occurs, are there some differences in neurogenesis and gliogenesis by the neural stem cells of different origins?

Key concepts: Gliogenesis, Neurogenesis, Neuroscience, Olfactory system, Nervous system, Central nervous system, Olfactory bulb, Biology

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