2005•Organic & Biomolecular ChemistryRequires access
Deprotonation–electrophile trapping of terminal epoxides
David M. Hodgson, Eirene H. M. Kirton, Steven M. Miles, Stéphanie Norsikian, Nigel J. Reynolds, Steven J. Coote
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Abstract
Organolithium-induced deprotonation of terminal epoxides in the presence of appropriate diamine ligands allows trapping with a range of electrophiles, yielding functionalised di- and tri-substituted epoxides in good yields and with control of stereochemistry at the epoxide.